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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3C2A
All Species:
13.64
Human Site:
S599
Identified Species:
33.33
UniProt:
O00443
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00443
NP_002636.2
1686
190680
S599
E
T
L
A
I
T
E
S
V
K
K
L
K
R
A
Chimpanzee
Pan troglodytes
XP_001172532
1686
190756
S599
E
T
L
A
I
T
E
S
V
K
K
L
K
R
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542517
1688
190811
S601
E
T
L
A
I
T
E
S
V
K
K
L
K
R
A
Cat
Felis silvestris
Mouse
Mus musculus
Q61194
1686
190739
E599
V
E
T
P
S
V
T
E
A
V
K
K
L
K
R
Rat
Rattus norvegicus
O70173
1505
170957
L475
V
S
D
A
V
K
E
L
T
L
I
L
Q
R
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510027
1689
189289
S602
E
T
L
A
V
T
E
S
V
K
R
L
K
R
A
Chicken
Gallus gallus
XP_421003
1693
190736
E605
V
E
T
P
A
I
T
E
S
V
K
K
L
R
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_700029
1738
195284
K618
R
T
R
S
P
E
S
K
M
F
F
Y
C
Y
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524028
1876
210456
I768
C
V
A
D
L
K
R
I
C
E
V
E
Q
K
K
Honey Bee
Apis mellifera
XP_396869
1681
191083
C574
V
D
N
F
V
N
A
C
C
Q
F
L
P
Q
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
93.5
N.A.
90.2
31.1
N.A.
83.3
75.4
N.A.
60.2
N.A.
32.5
33.9
N.A.
N.A.
Protein Similarity:
100
99.6
N.A.
96.8
N.A.
94.5
50.6
N.A.
90.2
85.4
N.A.
75.3
N.A.
51
54.7
N.A.
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
6.6
26.6
N.A.
86.6
13.3
N.A.
6.6
N.A.
0
6.6
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
13.3
46.6
N.A.
100
13.3
N.A.
20
N.A.
26.6
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
50
10
0
10
0
10
0
0
0
0
0
40
% A
% Cys:
10
0
0
0
0
0
0
10
20
0
0
0
10
0
0
% C
% Asp:
0
10
10
10
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
40
20
0
0
0
10
50
20
0
10
0
10
0
0
0
% E
% Phe:
0
0
0
10
0
0
0
0
0
10
20
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
30
10
0
10
0
0
10
0
0
0
0
% I
% Lys:
0
0
0
0
0
20
0
10
0
40
50
20
40
20
10
% K
% Leu:
0
0
40
0
10
0
0
10
0
10
0
60
20
0
0
% L
% Met:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
10
% M
% Asn:
0
0
10
0
0
10
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
20
10
0
0
0
0
0
0
0
10
0
10
% P
% Gln:
0
0
0
0
0
0
0
0
0
10
0
0
20
10
0
% Q
% Arg:
10
0
10
0
0
0
10
0
0
0
10
0
0
60
20
% R
% Ser:
0
10
0
10
10
0
10
40
10
0
0
0
0
0
0
% S
% Thr:
0
50
20
0
0
40
20
0
10
0
0
0
0
0
0
% T
% Val:
40
10
0
0
30
10
0
0
40
20
10
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _